New Phenylpnropanoid and Anti-inflammatory Cconstituents from the Aerial Parts of Eupatorium cannabinum subsp. Asiaticum

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標題:	New Phenylpnropanoid and Anti-inflammatory Cconstituents from the Aerial Parts of Eupatorium cannabinum subsp. Asiaticum
作者:	Yun-Chen Tsai (蔡允禎) Tsong-Long Hwang (黃聰龍) Jih-Jung Chen (陳日榮)
日期:	2011
上傳時間:	2011-06-23 14:57:32 (UTC+8)
摘要:	Eupatorium cannabinum subsp. Asiaticum (Compositae) is a perennial herb distributed in Himalaya mountain range, China, and Taiwan. E. cannabinum subsp. asiaticum, locally called 'Taiwan ze-lan' or iiu-yue-xue' has been used as a folk medicine to treat hepatitis, headache, diarrhea, hypertension, and diabetes mellitus in Taiwan. In our previous study, a new phenylpropanoid derivatives, 1-hydroxy-4-methylphenyl) propan-1,2-dione (1) and, two new benzofuranoids eupatobenzoforan (2), 2.hydroxy-2,6-dimethylbenzofuran-3(2/?)-one (3), and together with 5 known compounds, hofmeisterin II (4), l-[2-hydroxy-4-(hydroxy- methyl)phenyl]ethan-l-one (5), 10-acetoxy-8-hydroxy-9-O-angeloylthmol (6), β-sitosterol (7), and stigmasterol (8). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, and 6 exhibited inhibition (IC50 values < 13.1 uM) of superoxide anion generation and elastase release human neutrophils in response to formyl-L-methionyl- L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB).
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
显示于类别:	[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

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