Synthesis and Inhibition of RANKL-induced Osteoclastogensis of Indeno [1,2-c] quinoline Derivatives

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Title:	Synthesis and Inhibition of RANKL-induced Osteoclastogensis of Indeno [1,2-c] quinoline Derivatives
Authors:	You-Ren Chen (陳宥任) Chih-Hua Tseng (曾志華) Chiao-Li Yang (楊巧麗) Yeh-Long Chen (陳義龍) Cherng-Chyi Tzeng (曾誠齊)
Date:	2011
Issue Date:	2011-06-23 14:57:24 (UTC+8)
Abstract:	Certain indeno[l,2-c]quinolines were synthesized and evaluated for anti-osteoclastogenic activities. Among them, 6,9-dimethoxy-11H-indeno[l,2-c]- quinolin-11 -one (8a) and 9-methoxy-6-(methylthio)-11H-indeno[ 1,2-c] quinolin-11 -one (16a) inhibited RANKL-induced osteoclast formation in Raw 264.7 cells with an IC50 of 2.00 and 2.58 M respectively. Compound 8a was only weekly active in the inhibition of the RANKL-induced NFAT activation while 16a was inactive. These results indicated that the anti-osteoclastogenic effect of 8a is only partly related while 16a is not related to the suppression of NFAT.
Relation:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
Appears in Collections:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium

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