6-Alkylamino-2-(3-hydroxyphenyl)quinoIin-4-one Derivatives Induced Mitotic Arrest in Human Hep3B Cells

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會 > Item 310902800/24228

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/24228

標題:	6-Alkylamino-2-(3-hydroxyphenyl)quinoIin-4-one Derivatives Induced Mitotic Arrest in Human Hep3B Cells
作者:	Mei-Hua Hsu (徐美華) Li-Chen Chou (周立琛) Ming-Hua Chen (陳明華) Chi-Hung Huang (黃濟鴻) Hui-Yi Lin (林慧怡) Shi-Hon Zhuang (莊仕弘) Chien-Ting Chen (陳建廷) Li-Jiau Huang (黃麗嬌) Sheng-Chu Kuo ()
日期:	2011
上傳時間:	2011-06-23 14:57:19 (UTC+8)
摘要:	In order to develop potential backup compounds for our previous identified new anticancer drug candidate,CHM-l-P-Na, a series of 6-alkylamino-2-(3-hydroxyphenyl)quinolin-4-one derivatives were designed and synthesized. The newly synthesized derivatives were evaluated for cytotoxicity and structure-activity relationships were established. Among those tested compounds, 6-pyrrolidino-2-(3-hydroxyphenyl)quinolin-4-one (A) was the most promising agent which was submitted to NCI for evaluation against 60 human cancer cell lines. Furthermore, the monophosphate of compound A (A-P) was synthesized and evaluated for antitumor activity in Hep3B Xenograft nude mice model. The results indicated that compound A-P has excellent antitumor activity when administrated either iv or po. With excellent antitumor activity profiles, compound A-P is considered potential backup compound for CHM-l-P-Na, which is currently under preclinical study.
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
显示于类别:	[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

文件中的档案:

档案	描述	大小	格式	浏览次数
pp-12.pdf		70Kb	Adobe PDF	652	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....