Synthetic and Cytotoxic Studies on Alkyl 4-(3,4,5-trimethoxyphenoxy) benzoate

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會 > Item 310902800/24224

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標題:	Synthetic and Cytotoxic Studies on Alkyl 4-(3,4,5-trimethoxyphenoxy) benzoate
作者:	Wen-Yueh Ho (何文岳) Chia-Hua Liang (梁家華) Jui-Hsiang Hung (洪瑞祥) Wen-Jong Vong (汪文忠) Po-Jui Huang (黃博瑞) Kuan-Han Lee (李冠漢)
日期:	2011
上傳時間:	2011-06-23 14:57:16 (UTC+8)
摘要:	Diaryl ethers represent an important class of synthetic compounds recognized as potential anticancer drugs. Experimental and pre-clinical models have demonstrated that a number of these compounds elicit outstanding anticancer activity through the significant inhibition of tubulin assembly accompanied by potent antiproliferative activity. Moreover, the diaryl ether scaffold is found in a number of natural products and biologically important molecules, such as vancomycin and piperazinomycin. As a result of our continuing studies aimed at the discovery and development of potential anticancer agents, herein we report the synthesis, cytotoxic activities of a series of nlovel diaryl ethers. Diaryl ether (1) was synthesized via Ullmann-type coupling. Palladium(II) acetate catalyzed O-arylation reactions have been carried out in non-polar solvent and used K3PO4 as the base. Saponification in ethanolic NaOH solution afforded the acid form (2). Both compound 1 and 2 were shown selective cytotoxic activity against A549 (Human lung adenocarcinoma epithelial cell line) with the IC50 values of 2.1 μM and 12.3 μM, respectively.
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
顯示於類別:	[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會 [藥學系(所)] 會議論文 [化妝品應用與管理系(所)] 會議論文 [生物科技系(所)] 會議論文 [食藥產業暨檢測科技系(含五專)] 會議論文

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