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    標題: New Biphenyl from the Stem Bark of Magnolia officinalis
    作者: Wen-Lung Kuo (郭文龍)
    Ching-Yi Chung (鍾靜宜)
    Tsong-Long Hwang (黃聰龍)
    Jih-Jung Chen (陳日榮)
    日期: 2011
    上傳時間: 2011-06-23 14:57:13 (UTC+8)
    摘要: The stem bark of Magnolia officinalis Rehd. et Wils. (Magnoliaceae) has been used as a traditional medicine for the treatment of gastrointestinal disorders, bronchitis, and emphysema, in China, Taiwan, Japan, and Korea. Chemical studies have revealed a variety of neo-lignans and alkaloids as constituents of this plant. Many of these compounds exhibit central depressant effect, muscle relaxation, and antigastric ulcer, antibacterial, antiallergic, vasorelaxant, and neurotrophic activities. Investigation on EtOAc-soluble fraction of the stem bark of M. officinalis has led to the isolation of a new biphenyl, 5-allyl-5'-(l-hydroxyallyloxy)biphenyl-2,2-diol (1), together with 9 known compounds, including four neolignans, magnolol (2), honokiol (3), (-)-monoterpenylmagnolol (4), and randainal (5), a norlignan, magnaldehyde D( 6), and four steroids, β-sitostenone (7), stigmasta-4,22-dien-3-one (8), β-sitosterol (9), and stigmasterol (10). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, magnolol (2) and honokiol (3) exhibited potent inhibition against fMLP-induced superoxide production with IC50 value of 4.42 ± 0.24 and 0.88 ± 0.20 μg/mL, respectively. In addition, magnolol (2) inhibited fMLP/CB-induced elastase release with an IC50 values of 1.45 ± 0.20 μg/mL.
    關聯: 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會,起迄日:2011/04/06~2011/04/05,地點:溪頭台大實驗林
    顯示於類別:[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

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