English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17756/20057 (89%)
Visitors : 7928052      Online Users : 563
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/24215

    標題: Orange Polymethoxylated Flavones Suppress scavenger Receptor Expression in THP-1 Cells and Alter Lipid homeostasis in HepG2 Liver Cells
    作者: Jui-Hung Yen (顏瑞鴻)
    Ching-Yi Weng (翁菁憶)
    Shiming Li
    Ya-Hsuan Lo (駱雅萱)
    Ming-Hsiung Pan (潘敏雄)
    Shih-Hang Fu (傅士航)
    Chi-Tang Ho (何其儻)
    Ming-Jiuan Wu (吳明娟)
    日期: 2011
    上傳時間: 2011-06-23 14:57:08 (UTC+8)
    摘要: Nobiletin, a polymethoxyflavone (PMF) from the peel of Citrus fruit, has been reported to inhibit modified LDL uptake in macrophages and enhance hepatic LDL receptor expression and activity. We report the anti-atherogenic effect and mechanism of 5-demethylnobiletin, an auto-hydrolysis product of nobiletin. 5-demethylnobiletin significantly attenuated PMA-induced gene expression and activity of scavenger receptors, CD36, SR-A and LOX-1. The inhibitory effect is partly associated with the inhibition of PKC activity and JNK 1/2 phosphorylation, thereby inhibiting the activation of AP-1 and NF-κB. 5-demethylnobiletin treatment also led to reduction of oxLDL-induced CD36 mRNA expression and blockade of Dil-modified LDL uptake in THP-1-derived macrophages. In human hepatoma cell line HepG2, 5-demethylnobiletin significantly induced LDLR activity and transcription, at least in part, through SREBP-2 activation. 5-demethylnobiletin also decreased the mRNA expression of DGAT2, the key enzyme involved in the hepatic triacylglycerol biosyntheses. Current results suggest that 5-demethylnobiletin has diverse anti-atherogenic bioactivities. It is more potent in inhibiting monocyte-to-macrophage differentiation and foam cell formation than its permethoxylated counterpart, nobiletin. It exhibits similar hypolipidemic activity as nobiletin and both can enhance LDLR gene expression and activity and decreased DGAT2 expression.
    關聯: 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會,起迄日:2011/04/06~2011/04/05,地點:溪頭台大實驗林
    Appears in Collections:[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會
    [生物科技系(所)] 會議論文

    Files in This Item:

    File Description SizeFormat
    il-15.pdf97KbAdobe PDF479View/Open

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback