Synthesis, and Biological Evaluation of 2-Phenyl-bnenzothiazoles and Bis(benzylidene-benzenamine)-l-disulfides as Anticancer Agents

CNU IR > Pharmacy and Science > 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium > Item 310902800/24207

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Title:	Synthesis, and Biological Evaluation of 2-Phenyl-bnenzothiazoles and Bis(benzylidene-benzenamine)-l-disulfides as Anticancer Agents
Authors:	Jeh-Jeng Wang (王志鉦) Wan-Ping Hu (胡宛屏) Jaya Kishore Vandavasi
Date:	2011
Issue Date:	2011-06-23 14:57:02 (UTC+8)
Abstract:	Photodynamic therapy (PDT) employing exogenous photosensitizes is currently being approved for treatment of non-melanoma skin cancers such as basal cell carcinoma (BCC) and Bowen's disease. 2-phenyl-benzothiazoles (6), a group of chromophoric structure, absorb light in the UVA (315-400 nm) whereupon it becomes phototoxic through the prereduction of reactive oxygen species (ROS). In this presentation, we report a synthesis of 6 from phenylthiobenzamides (4) mediated by oxidative reagents1,2. Whhile reaction of 4 with DDQ formed bis[benzylidene-benzenamine]-l-disulfides (7) in high yields. The biological activities of compound 6 and 7 will also be reported3.
Relation:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
Appears in Collections:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium

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