Novel Metal-Based Antioxidants as Therapeutic Candidates for Protectors Against Oxidative stress

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會 > Item 310902800/24203

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/24203

標題:	Novel Metal-Based Antioxidants as Therapeutic Candidates for Protectors Against Oxidative stress
作者:	E. R. Milaeva N. S. Zefirov
日期:	2011
上傳時間:	2011-06-23 14:56:58 (UTC+8)
摘要:	A novel approach for the design of perspective candidates for the therapy of phatological states induced by oxidative stress is presented. The methodology is based on biomimetic construction of physiologically active biometals complexes and organometallic compounds with the ligands - analogues of natural antioxidants tocopherols. The synthesis, physico-chemical properties and biological activity of novel compounds containing 2,6-dialkylphenols will be discussed. The physiological activity has been evaluated in the in vitro, ex vivo, in vivo experiments in peroxidation of lipids in mitocfrchondria, neurons, rat and fish liver and brain homogenates, liposomes and lipids structural fragments, as well as in enzymatic reactions (xanthin oxidase, lipoxygenase, catalase, superoxide dismutase, cytochromes P450). The activity in oxidation reaction, solubility (logD), blood-brain barrier transfer (PAMPA, PAMPA BBB), inhibition of key enzymes of antioxidative defense system has been studied.The novel membrane-active compounds are perspective candidates as protectors against oxidative stress, mito- and neuroprotectors.
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
顯示於類別:	[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
il-03.pdf		106Kb	Adobe PDF	575	檢視/開啟

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....