Synthetic Development and Mechanistic Study on Pd(II)-Catalyzed Cyclization of Enediynes to Benzo[a]carbaxoles

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標題:	Synthetic Development and Mechanistic Study on Pd(II)-Catalyzed Cyclization of Enediynes to Benzo[a]carbaxoles
作者:	Chin-Chau Chen (陳景昭) Lin-Yu Chin (金玲宇) Shyh-Chyun Yang (楊世群) Ming-Jung Wu (吳明忠)
日期:	2011
上傳時間:	2011-06-23 14:56:54 (UTC+8)
摘要:	Treatment of N,N-dimethyl 2-[2-(2-ethynylphenyl)ethynyl] anilines (1) with 10 mol % of palladium chloride and 2 equiv of cupric chloride in n refluxing THF gave benzo[a]carbazoles (2) in good yields. A mechanistic study showed that this reaction must proceed through formation of haloindole (3) followed by a palladium(II)-catalyzed atom transfer cyclization reaction to give the benzo[a]carbazoles.
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
显示于类别:	[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

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