Synthesis and Aantiproliferative Evaluation of Monofluoro and Trifluoromethane-3,5-disubstituted 1,2,4-triazoles by Using Hydrazonoyl hydrochlorides with Aldehydes

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標題:	Synthesis and Aantiproliferative Evaluation of Monofluoro and Trifluoromethane-3,5-disubstituted 1,2,4-triazoles by Using Hydrazonoyl hydrochlorides with Aldehydes
作者:	Li-Ya Wang (王麗雅) Wen-Che Tseng (曾文哲) Shin-Hun Juang (莊聲宏) Fung Fuh Wong (翁豐富)
日期:	2011
上傳時間:	2011-06-23 14:56:48 (UTC+8)
摘要:	A series of monofluoro- and trifluoromethane-3,5-disubstituted 1,2,4-triazole compound was synthesized by using new efficient 1,3-dipolar cycloaddition method. This newly developed method was reaeacting hydrazonoyl hydrochlorides with a series of aldehydes in the presence of NEt3 as catalytic basic agent. The yielding cycloaddition products seemed not affect with the substituted on hydrazonoyl hydrochlorides. The preliminary asay d data indicate that some of of fluorine- and trifluoromethane-containing compounds can effectively be appbpJicable to inhibit ainst the growth of NCI-H226 and T-cell leukemia (Jurkat) two cells. In particular, trifluoromethane-containing 1,2,4-triazoles possessed the five membered ring groups on the C-5 position of triazolic ring, incuding cyclopentyl, 3-furyl, 3-thienyl, and 2-Pyrrolyl, possessed the significant inhibitory activity for NCI-H226.
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
显示于类别:	[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

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