English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 18085/20283 (89%)
造訪人次 : 5379927      線上人數 : 1008
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/2402


    標題: 印度紫檀抗癌活性成分之研究
    The study of Anticancer components from Pterocarpus indicus wild
    作者: 廖志中
    貢獻者: 化妝品應用與管理系
    關鍵字: Pterocarpus indicus,maackiain,medicarpin
    liquiritigenin
    pER8-GFP Reporter Assay
    estrogen-like activity
    日期: 2005
    上傳時間: 2008-07-31 14:37:52 (UTC+8)
    出版者: 台南縣:嘉南藥理科技大學化妝品應用與管理系
    摘要: 94 年度執行國科會計畫印度紫檀之抗癌活性成分之研究乙題,本實驗室已分離出近
    二十五個化合物, 其中包括六個三萜類化合物- lupeol 、betulinic acid 、betulin 、
    betulin-3-caffeate、friedelin 及3β-friedelinol;一個醣類化合物-sucrose;6 個固醇類化合物-
    β-sitosterol、stigmasterol、β-sitosteryl-3-O-β-D-glucoside、β-sigmasteryl-3-O-β-D- glucoside、
    β-sitosterone 及stigmasterone;1 個沒食子酸類衍生物- 3,4,5-trihydroxy-benzaldhyde;以及
    十一個異黃酮類化合物- maackiain 、pterocarpine 、homopterocarpin 、angolensin 、
    3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)propan-1-one 、medicarpin 、
    secundiflorol I、liquiritigenin、4’-methoxyl-7-hydroxyl-2,3-dihydroisoflavone、PI-S24-4 以及
    PI-S33-2。其中pterocarpine 異黃酮類化合物為文獻所記載之紫檀主要活性成分,而
    3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxy-phenyl)propan-1-one、Afromosin 以
    及PI-S33-2 為首次自天然資源中分離出之化合物。此外,除pterocarpine 與angolensin 外,
    其他皆為自此種植物中首次分離獲得的;此外,在經雌激素基因轉殖植物篩選測試,
    maackiain (1),medicarpin (7),liquiritigenin (9) 顯示具有類雌激素之作用。其他相關之活
    性作用正在進一步測試中。
    Based on the screening data of the extracts from Formosan plants and folk medicine by
    National Research Program, Pterocarpus indicus Willd. was found to be active toward cancer
    disease. The preliminary bioassay indicated that the methanol extract of the bark of P. indicus
    exhibited 52% inhibitory activity against ovarian cancer cells, Hela cells, at the concentration of
    50 μg/mL. In this year, a series of natural-occurring compounds, including 11 isoflavonoid
    compounds, 6 triterpenoids, and 6 steroids, were isolated and purified from the bark extract of
    this plant by column chromatography and high performance liquid chromatography (HPLC). The
    structures of all isolates were elucidated and characterized by spectral methods. Among them,
    compound 1 was isolated from the natural sources for the first time. Except for pterocarpine and
    angolensin, others were isolated from this plant fro the first time. In addition, maackiain (1),
    medicarpin (7), liquiritigenin (9) showed estrogen-like activity by the pER8-GFP reporter assay.
    Other bioactivities of these isolates are under investigation.
    關聯: 計畫編號: NSC94-2320-B-041-011
    顯示於類別:[化妝品應用與管理系(所)] 科技部計畫

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    NSC94-2320-B-041-011.pdf270KbAdobe PDF1389檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋