Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/23519
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    標題: 台灣軟珊瑚Sarcophyton tenuispiculatum所含天然成分之研究
    作者: 王貴弘
    貢獻者: 化粧品應用與管理系
    關鍵字: Sarcophyton tenuispiculatum
    cembranoids
    cytotoxic
    日期: 2010
    上傳時間: 2011-02-22 15:39:30 (UTC+8)
    摘要: Soft corals are well known for their high content of diterpenes and particularly. In the course of our study on the chemical constituents of soft corals, we have isolated many chemically and biologically interesting secondary metabolites. Soft coral of the genus Sarcophyton (family, Alcyoniidae) have been reported to contain a variety of cembranoids. Unusual dimeric terpenoid skeletons have also been isolated from this genus, and these structures have been proposed to originate by Diels-Alder addition of two different cembranoid units. Recently, we isolation a new skeleton biscembranoid from the Formosan soft coral Sarcophyton tenuispiculatum. The structure was determined by 1D and 2D NMR spectral analysis. The relative stereochemistry of compound was secured by X-ray diffraction analysis. This study demonstrates the cytotoxic effects of this metabolite on SCC25, A431, A375, A549 and HepG2 cells.
    關聯: 計畫編號:CN9932;計畫年度:99
    显示于类别:[化妝品應用與管理系(所)] 校內計畫

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