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    Title: Unlocking Fungal Cryptic Natural Products
    Authors: Yi-Ming Chiang
    Kuan-Han Lee
    James F. Sanchez
    Nancy P. Keller
    Clay C. C. Wang
    Contributors: 藥物科技研究所
    Keywords: natural products biosynthesis
    genomic mining
    polyketide synthase
    nonribosomal peptide synthetase
    Date: 2009-11
    Issue Date: 2010-12-29 14:19:44 (UTC+8)
    Abstract: Recent published sequencing of fungal genomes has revealed that these microorganisms have a surprisingly large number of secondary metabolite pathways that can serve as potential sources for new and useful natural products. Most of the secondary metabolites and their biosynthesis pathways are currently unknown, possibly because they are produced in very small amounts and are thus difficult to detect or are produced only under specific conditions. Elucidating these fungal metabolites will require new molecular genetic tools, better understanding of the regulation of secondary metabolism, and state of the art analytical methods. This review describes recent strategies to mine the cryptic natural products and their biosynthetic pathways in fungi.
    Relation: Natural Product Communications 4(11):p.1505-1510
    Appears in Collections:[Dept. of Pharmacy] Periodical Articles

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