以人體藥物參數值尋求最佳室體模式之研究

CNU IR > Chna Nan Annual Bulletin > Vol.18 (1992) > Item 310902800/23276

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Title:	以人體藥物參數值尋求最佳室體模式之研究 Searching for The Optimal Compartment Modelization by Parameter Value
Authors:	王又英陸海林
Contributors:	嘉南藥學專科學校
Date:	1992
Issue Date:	2010-11-29 10:43:35 (UTC+8)
Abstract:	在藥物動力學( phamacokinetics)上，我們對藥物投入人體中，通過吸收、分佈、代謝及排泄等速率過程，應屬於何種室體模式( compartment body model )，這些不同室體模式伴隨著不同的係數值，而這些係數值對藥物在體內動態有甚為重要的描述，故求出適當的模式為本文目的。本文以數值例對三種室體，及以藥物中動差( Moment)性質各別加以求出之0—階、1—階、 2—階動差，做比較，求出較適合之室體模式，以做藥物動力學參數求值之基準。 In pharmacokinetics, when drug dosage is appliced to human body, which compartment body model does the dosage go to by.the process of absorption, distribution, biotransformation and excreation? Those different compartment body models are accompanied with different coefficient ,value which has a very important influence on parameter of drug dosage. The parameter value of pharmacokinetics contributes to a description of the development of drug in physical body. The research is aimed at finding out the proper model. On the basis of three compartment body models and statistical Moment of drug dosage, we can work out the O-Factorial ` 1-Factorial and 2-Factorial. We may find out the appropriate compartment body model which can be used as a rule of the parameter value of pharmacokinetics.
Relation:	嘉南學報 18期 : p.44-52
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.18 (1992)

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