Hypotensive and antinociceptive effects of ether-linked and relatively non-pungent analogues of N-nonanoyl vanillylamide

CNU IR > Chna Nan Annual Bulletin > Vol.18 (1992) > Item 310902800/23271

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题名:	Hypotensive and antinociceptive effects of ether-linked and relatively non-pungent analogues of N-nonanoyl vanillylamide
作者:	IJ Chen JM Yang JL Yeh BN Wu YC Lo SJ Chen
关键词:	capsaicin hypotensive activity antinociceptive activity non-pungent analogues
日期:	1992
上传时间:	2010-11-29 10:38:41 (UTC+8)
摘要:	N-nonanoyl vanillylamide (1) is a synlhetic substitute of capsaicin (2), a pungent principle in red pepper. 1 was reacted with succinic anhydride. 3-chloro-1,2-propanediol, sodium chloroacetate, and 2-chloroethanol to furnish N-nonanoyl vanillylamide-4-succinyl ester (3), N-nonanoyl vanillylamide-4-glyceryl ether (4), sodium N-nonanoyl vanillylamide-4-O-acetate (5) and N-nonanoyl vanillylamide-4-glyceryl ether (6), respectively. A 3,4-methylenedioxy derivative of 1, N-nonanoyl piperonylamide (7), was synthesized form piperonylamine HCl and nonaoyl chloride. The ether analogues 4-6 all demonstrated marked antinociceptive and hypotensive effects without producing any overt irritation. In addition, these compounds revealed no untoward vagus reflex or transient hypertensive effect as previously found in 1 or 2.
關聯:	嘉南學報 18期:p.A8-A13轉載Eur J Med Chem 27(3):p.187-192 (1992年)
显示于类别:	[Chna Nan Annual Bulletin] Vol.18 (1992)

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