Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia

doi:10.1016/j.cca.2009.03.041

CNU IR > College of Sustainable Environment and Recreation > Dept. of Occupational Safety > Periodical Articles > Item 310902800/23265

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/23265

Title:	Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia
Authors:	Hung-Yuan Li Jung-Nan Wei Mao-Shin Lin David J. Smith Jani Vainio Cheng-Hsin Line Fu-Tien Chiang Shyang-Rong Shih Ching-Huei Huang Mei-Yu Wu Yenh-Chen Hsein Lee-Ming Chuang
Contributors:	職業安全衛生系
Keywords:	Semicarbazide-sensitive amine oxidase Vascular adhesion protein-1 Amine oxidase Copper-containing 3 (AOC3) Diabetes mellitus Diabetic complications
Date:	2009-06
Issue Date:	2010-11-19 11:50:22 (UTC+8)
Abstract:	Background The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes. Methods Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay. Results We recruited 333 subjects (186 females and 147 males), aged 56.1 ± 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p < 0.0001) and lasted until 2 h (p < 0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = − 0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG ≥ 5.55 mmol/l (p = 0.025) but not in those with FPG < 5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference. Conclusions Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.
Relation:	Clinica Chimica Acta 404(2)：p.149-153
Appears in Collections:	[Dept. of Occupational Safety] Periodical Articles

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