Change of serum vascular adhesion protein-1 after glucose loading correlates to carotid intima-medial thickness in non-diabetic subjects

doi:10.1016/j.cca.2009.01.027

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 職業安全衛生系(含防災所) > 期刊論文 > Item 310902800/23261

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標題:	Change of serum vascular adhesion protein-1 after glucose loading correlates to carotid intima-medial thickness in non-diabetic subjects
作者:	Hung-Yuan Li Mao-Shin Lin Jung-Nan Wei Chi Sheng Hung Fu-Tien Chiang Cheng-Hsin Lin Hsiu-Ching Hsu Chien-Yin Su Mei-Yu Wu David J. Smith Jani Vainio Ming-Fong Chen Lee-Ming Chuang
貢獻者:	職業安全衛生系
關鍵字:	Carotid intima-medial thickness Vascular adhesion protein-1 Oxidative stress Advanced glycated end products
日期:	2009-05
上傳時間:	2010-11-19 11:50:11 (UTC+8)
摘要:	Background We investigated if serum vascular adhesion protein-1 (SSAO/VAP-1) changed acutely following oral glucose loading and whether such changes are correlated with surrogate markers of atherosclerosis. Methods A total of 115 non-diabetics subjects were enrolled for an oral glucose tolerance test (OGTT). Carotid intima-medial thickness (IMT) was measured by ultrasonography. Serum SSAO/VAP-1 was analyzed by time-resolved immunofluorometric assay. Serum thiobarbituric acid reactive substances (TBARS) and advanced glycated end products (AGEs) were measured by fluorometric assays. Results Serum SSAO/VAP-1 increased significantly at 30 min after oral glucose loading and lasted to 2 h (p = 0.0005 and p < 0.0001, for 30 min and 2 h respectively). The area under curve of serum SSAO/VAP-1 during OGTT (AUC-VAP-1) correlated significantly with carotid IMT, independent of age, gender, low-density lipoprotein cholesterol, systolic blood pressure, hemoglobin A1c, serum TBARS, AGEs, and high-sensitivity C-reactive protein. Subjects with a positive AUC-VAP-1 had significantly higher serum TBARS and AGEs than subjects with a negative AUC-VAP-1 adjusted for age and gender. Conclusions Serum SSAO/VAP-1 changed acutely following oral glucose loading in non-diabetic subjects. Change of serum SSAO/VAP-1 correlated independently to serum TBARS, AGEs, and carotid IMT. Our findings suggest that acute change of serum SSAO/VAP-1 is a novel marker for hyperglycemia-induced atherosclerosis.
關聯:	Clinica Chimica Acta 403(1-2)：p.97-101
顯示於類別:	[職業安全衛生系(含防災所)] 期刊論文

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