New cytotoxic withanolides from Physalis peruviana

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Title:	New cytotoxic withanolides from Physalis peruviana
Authors:	Yu-Hsuan Lan Fang-Rong Chang Mei-Jung Pan Chin-Chung Wu Shu-Jing Wu Su-Li Chen Shyh-Shyan Wang Ming-Jung Wu Yang-Chang Wu
Contributors:	保健營養系
Keywords:	Physalis peruviana L. Withanolides Phyperunolide A–F Peruvianoxide Cytotoxicity
Date:	2009-09
Issue Date:	2010-11-12 16:11:29 (UTC+8)
Abstract:	Investigation of the extracts of Physalis peruviana L. has led to the isolation of seven new withanolides, phyperunolide A (1), phyperunolide B (2), phyperunolide C (3), phyperunolide D (4), peruvianoxide (5), phyperunolide E (16), and phyperunolide F (17) together with ten known withanolides. The structure and absolute stereochemistry of all compounds were elucidated on the basis of CD and NMR spectral analysis, respectively. Compounds 1, 6, 7, and 9 showed cytotoxicity against lung cancer (A549), breast cancer (MDA-MB-231 and MCF7), and liver cancer (Hep G2 and Hep 3B) cancer cell lines. The presence of 5β,6β-epoxy-2-en-1-ones in withanolides is greatly helpful in cytotoxicity, it is a key known important factor to cytotoxicity; however, interestingly, the unusual 5-chloride withanolide, 9, displayed significant activity.
Relation:	Food Chemistry 116(2)：p.462-469
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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