Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/23212
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    標題: Effects of Pregnenolone-16α-Carbonitrile on Vitamin E Status and Protein Levels of Antioxidant Enzymes in Male Rats Fed a Vitamin E-Supplemented Diet
    作者: Huey-Mei Shaw
    Wan-Hsuan Chen
    貢獻者: 保健營養系
    關鍵字: α-tocopherol
    TBARS
    antioxidant enzyme
    cytochrome P450
    rat
    日期: 2009-04
    上傳時間: 2010-11-12 16:11:27 (UTC+8)
    摘要: The aim of this study was to evaluate the effects of the administration of pregnenolone-16α-carbonitrile (PCN), an inducer of the cytochrome P450 3A gene in rats, on vitamin E status and antioxidant enzyme protein levels in rats fed a vitamin E-supplemented diet. Two groups of male Wistar rats were fed for 3 weeks with a basal diet containing 50 ppm of α-tocopherol or the same diet containing 10 times more α-tocopherol. In the final 3 days, each group was divided into two subgroups which were given a single daily intraperitoneal injection of PCN at 75 mg/kg (groups PCN and PCN+VE) or DMSO (groups DS and DS+VE). PCN treatment alone significantly reduced
    the α-tocopherol content of the liver and plasma and this effect was prevented by supplementation
    with 10-fold more α-tocopherol. α-Tocopherol levels in the kidneys, lung, heart, and testes were significantly higher in both vitamin E-supplemented groups than in the control groups. TBARS levels in the liver and lung were significantly increased in both PCN-treated groups, as shown by two-way ANOVA analysis. PCN also caused a significant reduction in protein levels of catalase and glutathione peroxidase (GPx) in both groups. Dietary vitamin E supplementation caused a decrease in liver protein levels of GPx and superoxide dismutase, but not catalase, in both groups and protected against PCN-induced lipid peroxidation, which was caused by CYP3A induction and a reduction in antioxidant enzyme levels.
    關聯: Redox Report 14(2)：p.61-38
    顯示於類別:[保健營養系(所) ] 期刊論文

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