番椒晶素及SNA對人類血小板的抑制作用

Chia Nan University of Pharmacy & Science Institutional Repository > 嘉南學報 > 20期 (1994) > Item 310902800/23178

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標題:	番椒晶素及SNA對人類血小板的抑制作用 Studies on the Antiplatelet Activities of Capsaicin and SNA
作者:	楊竹茂游慧美高惠珍傅利芳
貢獻者:	藥學科
關鍵字:	番椒晶素 SNA 抗血小板凝集活性 ADP 膠原旦白血小板活化因子 capsaicin sdium nonivamide acatate anti-platelet activity ADP collagen PAF
日期:	1994
上傳時間:	2010-11-10 18:22:23 (UTC+8)
摘要:	本研究旨在探討番椒晶素語合成的同類物SNA（Sodium Nonivamide Acetate）的抗血小板凝集作用之活性與機轉，由一系列實驗顯示：二者皆能抑制膠原蛋白所誘發之血小板凝集作用；番椒晶素顯示對綿羊精囊微粒體催化花生烯酸產生前列腺素E2具有強烈的抑制作用，然而SNA並無此作用；兩者對徑indomethacin處理與未處理之人體血小板微粒體（IPM）催化花生烯酸所產生的凝血素B2具有劑量相關性的抑制作用；兩者皆能抑制以螺旋條狀的兎主動脈所進行的生物檢測法中，由IPM催化前列腺素內過氧化物產生凝血素 The aim of this study is to investigate the and-platelet aggregation activities and the possible mechanisms of action of capsaicin (CAP) and the synthetic analogue-SNA (Sodium Nonivamide Acetate). The results obtained from a series of experiments demonstrated that both cmpounds in-hibited the platelet aggregation induced by collagen; CAP also showed a strong inhibition on PGE2 formation from 【14C】 A.A. by sheep seminal vesicle (SSV) microsomes, while SNA did not have this effect. Both drugs produced a dose-dependent inhibition of TXB2 formation from【14C】A.A. by human platelet microsomes and from PG-endoperoxides by indomethacin-treated human platelet microsomes (IPM). In the bioassay with spiral strip of rabbit-aorta, both drugs inhibited the formation of TXA2-like form PG-endoperoxides by IPM. In conclusion, the anti-platelet effect of SNA might be due to the selective inhibition of thro-mboxane synthetase activity in human platelets.
關聯:	嘉南學報 20期：p.204-220
顯示於類別:	[嘉南學報] 20期 (1994) [藥學系(所)] 期刊論文

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