The protective efficacy of magnolol in hind limb ischemia-reperfusion injury

doi:10.1016/j.phymed.2009.03.001

CNU IR > Pharmacy and Science > Dept. of Biotechnology (including master's program) > Periodical Articles > Item 310902800/23146

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/23146

Title:	The protective efficacy of magnolol in hind limb ischemia-reperfusion injury
Authors:	Hung-Yi Chena Yu-Chang Hung E-Jian Leea Tsung-Ying Chen I-Chuan Chuang Tian-Shung Wu
Contributors:	生物科技系
Keywords:	Ischemic limb injury Antioxidant Anti-nitrosative Anti-inflammation Magnolol
Date:	2009-10
Issue Date:	2010-10-27 14:14:40 (UTC+8)
Abstract:	We investigated the protective effects of magnolol, an active antioxidant and free radical scavenger extracted from Magnolia officinalis, in a hind limb ischemic-reperfusion animal model. Adult male Spraque-Dawley rats were subjected to hind limb ischemic insult for 2 hours and were intravenously treated with magnolol at 0.01mg/kg (n=8), 0.3mg/kg (n=8)mg/kg or 1mg/kg (n=8)mg/kg, or vehicle (n=8). At 24h post-insult, the levels of nitrite/nitrate (NOX), malondialdehyde (MDA) and myeloperoxidase (MPO), as well as the degree of muscle damage, were assessed. Relative to controls, animals treated with magnolol (0.3 and 1mg/kg) had attenuated muscular inflammation, edema and damage. Magnolol (0.3–1mg/kg) also effectively reduced postischemic rises in the MDA, NOx and MPO levels (p<0.05, respectively). Magnolol administrated at 0.01mg/kg, however, failed to protect against the ischemic-perfusion limb injury. In addition, magnolol (0.01–1mg/kg) did not affect local muscular blood reperfusion or other physiological parameters, including hematocrit, glucose, arterial blood gases and mean arterial blood pressure. Thus, intravenous administration with magnolol at 0.3–1mg/kg protects against ischemic limb damage in rats. This cytoprotection may be attributed to its antioxidant, anti-nitrosative and anti-inflammatory actions.
Relation:	Phytomedicine 16(10)：p.976-981
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles

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