Cyphomandra betacea Sendt. phenolics protect LDL from oxidation and PC12 cells from oxidative stress

doi:10.1016/j.lwt.2008.09.010

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 生物科技系(所) > 期刊論文 > Item 310902800/23140

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/23140

標題:	Cyphomandra betacea Sendt. phenolics protect LDL from oxidation and PC12 cells from oxidative stress
作者:	Mei-Chun Kou Jui-Hung Yen Jing-Ting Hong Chia-LingWang Chia-Wei Lin Ming-JiuanWu
貢獻者:	生物科技系
關鍵字:	C. betacea Antioxidant effect LDL oxidation PC12 cells ROS
日期:	2009-03
上傳時間:	2010-10-27 14:14:24 (UTC+8)
摘要:	Cyphomandra betacea Sendt. (tamarillo) is a subtropical fruit containing rich contents of anthocyanins and carotenoids. The antioxidant activity was investigated using a crude ethanol extract of C. betacea fruit and its partitioned fractions, i.e. the ethyl acetate, butanol and water fractions. The ethyl acetate fraction exhibited the highest DPPH scavenging activity, Trolox equivalent antioxidant capacity (TEAC) and total phenol content. C. betacea phenolics in ethyl acetate fraction inhibited copper-induced LDL oxidation equally to or more effectively than dl-α-tocopherol, as measured by decreased formation of thiobarbituric acid-reactive substances (TBARS), conjugated diene and relative electrophoretic mobility (REM). Furthermore, 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) reduction assay showed that C. betacea phenolics in ethyl acetate fraction prevent oxidative stress-induced cell death in neuronal PC12 cells in a dose-dependent manner via attenuation of ROS production. In conclusion, C. betacea phenolics are potent antioxidants which can inhibit LDL oxidation in vitro and ROS production in PC12 cells.
關聯:	LWT - Food Science and Technology 42(2)：p.458-463 Elsevier Science
显示于类别:	[生物科技系(所)] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	2047	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....