Analgesic and anti-inflammatory activities of a water extract of Trachelospermum

doi:10.1016/j.jep.2009.08.019

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標題:	Analgesic and anti-inflammatory activities of a water extract of Trachelospermum
作者:	Ming-Jyh Sheu Pei-Yu Chou Hsu-Chen Cheng Chieh-Hsi Wu Guan-Jhong Huang Bor-Sen Wang Jwo-Sheng Chen Yi-Chung Chien Ming-Hsing Huang
貢獻者:	化粧品應用與管理系食品科技系
關鍵字:	Trachelospermum jasminoides Analgesic Anti-inflammation NO TNF-α MDA
日期:	2009-11
上傳時間:	2010-10-26 16:06:45 (UTC+8)
出版者:	Elsevier
摘要:	Aims of the study This study investigated the analgesic and anti-inflammatory effects of a water extract of Trachelospermum jasminoides (WET) in ICR mice. Materials and methods In HPLC analysis, the fingerprint chromatogram of WET was established. Acetic acid-induced writhing response and formalin-induced pain were examined the analgesics effects of WET. WET on λ-Carrageenan(carr)-induced paw edema was performed. We investigate the anti-inflammatory mechanism of WET via studies of the activities of glutathione peroxidase (GPx), glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and nitrite oxide (NO) in the edema paw. Serum NO and TNF-α were also measured. Results The fingerprint chromatogram of WET was established through HPLC analysis, and implies that WET contains the active ingredient gallic acid, chlorgenic acid, caffeic acid, taxifolin, isoquercitrin and quercetin. WET significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase. In the anti-inflammatory test, WET inhibited the development of paw edema induced by carr. WET decreased the paw edema at the third, fourth and fifth hour after carr administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after carr injection. WET decreased the level of NO in edematous paw tissue and in serum level, and diminished the level of serum TNF-α at the fifth hour after carr injection. Conclusions These results demonstrated that WET is an effective anti-inflammatory agent in carr-induced inflammation. WET probably exerts anti-inflammatory effects by suppressing TNF-α and NO. The anti-inflammatory mechanism of WET might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.
關聯:	Journal of Ethnopharmacology 126(2)：p.332-338
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文 [ 食品科技系 ] 期刊論文

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