本研究利用聚電解質複合反應（polyelectrolyte complexation），將含Acetazolamide藥物的海藻酸鈉（sodium alginate）高分子膠體溶液滴入幾丁聚醣（chitosan）/醋酸/氯化鈣中，進行聚電解質複合反應，形成互穿型網狀（interpenetration network, IPN）結構，生成一次膠體顆粒（primary particle）。再加入適量的三聚磷酸鈉（sodium tripolyphosphate）使chitosan沉澱堆積在一次膠體顆粒之表面上形成二次膠體顆粒（secondary particle）。改變海藻酸鈉、Acetazolamide與氯化鈣之添加量而得到不同之SA/AA/Ca2＋/Chit含藥之膠體顆粒。探討製備條件之不同對藥物包埋量、藥物顆粒重量平均粒徑、顆粒孔體積（pore volume）、顆粒表面積、顆粒表面形態（morphology）及釋放環境（pH2、7）對藥物釋放模式之影響。 The purpose of this study was the preparation and investigation of drug containing polymer gel beads. Different beads were obtained by polyelectrolyte complexation of chitosan, sodium alginate and calcium chloride to form interpenetration network (IPN) primary particles. The secondary particles were accomplished on the surface chitosan of the primary particles via the ionic-crosslinking with sodium tripolyphosphate. The effect of drug entrap ratio, drug distribute density, total pore volume, morphology and physical properties on drug released behavior were investigated. The results showed that the drug can prolong about 9 hr at pH2 and its release rate was consistent with T. Higuchi model.
