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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22539

    標題: Use of Phospholipids to Enhance the Intestinal Absorption of Epirubicin
    作者: Yu-LiLo
    貢獻者: 藥學系
    關鍵字: epirubicin
    multidrug resistance
    日期: 1999
    上傳時間: 2010-04-08 13:05:58 (UTC+8)
    摘要: Studies using cancer chemotherapeutic agents such as epirubicin encapsulated in liposomes, made of phospholipids and other ingredients, have generally shown reduced toxicity and enhanced therapeutic efficacy. This study investigated the effects of liposomal encapsulation,empty liposome or free lipid addition on the uptake and transport of epirubicin in the human colon adenocarcinoma (Caco-2) cell line. The flow cytometric experiments showed that liposomal encapsulation or empty liposome addition significantly increased the intracellular accumulation or epjrubicin in Caco-2 cells. Use of liposomes, made of dipalmitoyl phosphatidylcholine (DPPC), substantially enhanced apical to basolateral absorption of epirubicin across Caco-2 monolayers. Furthermore,except free DPPC addition, epirubicin encapsulated in DPPC liposomes or empty DPPC liposome addition significantly reduced the basolateral to apical efflux of epirubicin across Caco-2 mono-layers. The study suggests that inhibition of P-gp or other transporter proteins located in the intestines may be, at least partially, involved in the reduction of epirubicin efflux. In conclusion,the therapeutic efficacy of epirubicin may be improved by the use of phospholipids as excipients and MDR modulators in the formulations. Liposomal encapsulation may have significant implications to circumvent drug reslstance in cancer chemotherapy.
    關聯: 嘉南學報 25 : p.139-146
    Appears in Collections:[嘉南學報] 25 期 (1999)
    [藥學系(所)] 期刊論文

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