In the development of controlled release dosage forms for oral administration, we attempt to prepare pellets using binary mixtures of Avicel and lactose as bulk materials by extrusionspheronization method. Nicardipine HCl was chosen as a model drug at a concentration of 5%(w/w).The present study was performed to obtain basic information for factors effecting granulation and drug release characteristics of pellets. The results indicated that the technique is suitable to obtain pellet of particle sizes ranging from 500 to 3000μm. The granulatablility of pellets and the drug dissolution was optimal chitosan concentration was around O.2 % (w/w). Furthermore, The interaction among the components of pellet was examined by DSC. 在研發經口投與之藥物控釋劑型的前提下，我們嘗試使用Avcel與乳糖二者混合物經由擠出搓圓技術來製備圓粒，並選擇nicard ipne HCI為模式藥物;添加濃度為重量百分比5%。本研究在探討影響圓粒圓度與其藥物釋離特性之因素，以獲致有關的基本資訊。結果指出，此製備技術所產製的圓粒其粒徑介於500至3000 m之間，圓粒的成粒與藥物溶離可藉由添加chitosan在黏合劑中而獲得極大的改善，而適宜的chitosan添加濃度是重量百分比0.2%。至於圓粒中各組成分之間的交互作用，則採用熱分析來加以檢測。
