Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/22294
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    题名: Determination of norfloxacin in rat liver perfusate using capillary electrophoresis with laser-induced fluorescence detection
    作者: Ching-Ling Cheng
    Chia-Hung Fu
    Chen-Hsi Chou
    贡献者: 藥學系         
    关键词: Capillary electrophoresis
    Hepatic disposition
    Norfloxacin
    Perfused rat liver
    Laser-induced fluorescence
    日期: 2007-09
    上传时间: 2010-01-15 14:39:59 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: A capillary zone electrophoresis method has been developed for the direct determination of norfloxacin in the physiological perfusate of isolated rat liver. Norfloxacin and the internal standard triamterene were detected using laser-induced fluorescence (LIF) detection with the excitation and emission wavelength of 325 and 435 nm, respectively. The background electrolyte (BGE) was 50 mM phosphate buffer (pH 4.6). The effect of pH and concentration of BGE on the electrophoretic migration and fluorescence response of analytes were examined. Calibration curves were linear over a wide range of 0.01–100 μg/mL. The limit of quantitation was 0.01 μg/mL. The intra- and inter-day relative standard deviation was 3.7%, or less, and the accuracy was 93.2% of the nominal concentration. No endogenous substances were found to interfere. The method was used to characterize the steady-state and transient pharmacokinetics of norfloxacin in the rat liver.
    關聯: Journal of Chromatography B 856(1-2): p.381-385
    显示于类别:[Dept. of Pharmacy] Periodical Articles

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