Ester prodrugs of morphine improve transdermal drug deliver: a mechanistic study

doi:10.1211/jpp.59.7.0002

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/22289

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/22289

Title:	Ester prodrugs of morphine improve transdermal drug deliver: a mechanistic study
Authors:	Wang, Jhi-Joung Sung, K.C. Huang, Jeng-Fen Yeh, Chih-Hui Fang, Jia-You
Contributors:	藥物科技研究所
Date:	2007-07
Issue Date:	2010-01-15 14:39:50 (UTC+8)
Publisher:	Pharmaceutical Press-Royal Pharmaceutical Soc Great Britian
Abstract:	Two alkyl esters of morphine, morphine propionate (MPR) and morphine enanthate (MEN), were synthesized as potential prodrugs for transdermal delivery. The ester prodrugs could enhance transdermal morphine delivery. The mechanisms of this enhancing effect were elucidated in this study. Both prodrugs were more lipophilic than their parent drug as evaluated by the skin/vehicle partition coefficient (log P) and capacity factor (log K′). The in-vitro skin permeation of morphine and its prodrugs from pH 6 buffer was in the order of MEN > MPR > morphine. MPR and MEN respectively enhanced the transdermal delivery of morphine by 2- and 5-fold. A contrary result was observed when using sesame oil as the vehicle. The prodrugs were stable against chemical hydrolysis in an aqueous solution, but were readily hydrolysed to the parent drug when exposed to skin homogenate and esterase. Approximately 98% MPR and ∼75% MEN were converted to morphine in an in-vitro permeation experiment. The viable epidermis/dermis contributed to a significant resistance to the permeation of ester prodrugs. According to the data of skin permeation across ethanol-, α-terpineol-, and oleic acid-pretreated skin, MEN was predominantly transported via lipid bilayer lamellae in the stratum corneum. The intercellular pathway was not important for either morphine or MPR permeation.
Relation:	Journal of Pharmacy and Pharmacoiogy 59(7)： p.917-925
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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