Tetrandrine inhibits proinflammatory cytokines, iNOS and Cox-2 expression in human monocytic cells

doi:10.1248/bpb.30.59

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/22223

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题名:	Tetrandrine inhibits proinflammatory cytokines, iNOS and Cox-2 expression in human monocytic cells
作者:	Shu-Jing Wu Lean-Teik Ng
贡献者:	營養與保健科技研究所
关键词:	cytokine inducible nitric oxide synthase (iNOS) COX-2 THP-1 cell
日期:	2007-01
上传时间:	2010-01-15 11:13:28 (UTC+8)
摘要:	Tetrandrine (TET), a bis-benzylisoquinoline alkaloid isolated from the dried root of Hang-Fang-Chi (Stephania tetrandra S. MOORE), is traditionally used in China for treating inflammation, hypertension and silicosis. In this study, our aim was to examine the anti-inflammatory mechanism of TET through measuring the inducible nitric oxide synthase (iNOS), cyclooxygenase-1, and -2 (COX-1 and COX-2) expression, cytokines (TNF-α, IL-4 and IL-8) formation, nitric oxide (NO) release and prostaglandin E2 (PGE2) generation in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells. Results showed that TET remarkably suppressed the LPS (1 μg/ml) induction of NO release and PGE2 generation. It also significantly attenuated the LPS-induced transcription of proinflammatory cytokines (TNF-α, IL-4 and IL-8) in a dose-dependent manner. Furthermore, TET at 100 μM significantly blocked the LPS induction of iNOS and COX-2 expression, but not the COX-1. Taken together, these results suggest that TET exerts anti-inflammatory effects probably through the suppression of COX-2 and iNOS expression.
關聯:	Biological & Pharmaceutical Bulletin 30(1)： p.59-62
显示于类别:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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