Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by pterocarnin A from the bark of Pterocarya stenoptera via the Fas-mediated pathway.

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標題:	Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by pterocarnin A from the bark of Pterocarya stenoptera via the Fas-mediated pathway.
作者:	Kuo, Po-Lin Hsu, Ya-Ling Sung, Shu-Chiao Ni, Wen-Chiu Lin, Ta-Chen Lin, Chun-Ching
貢獻者:	生物科技系
日期:	2007-06
上傳時間:	2010-01-12 09:13:12 (UTC+8)
出版者:	Lippincott Williams & Wilkins
摘要:	Pterocarnin A, isolated from the bark of Pterocarya stenoptera (Juylandaceae), was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identify the anticancer mechanism of pterocarnin A, we assayed its effects on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that pterocarnin A induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that the Fas/Fas ligand apoptotic system is the main pathway of pterocarnin A-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of pterocarnin A in MCF-7 cells.
關聯:	Anti-Cancer Drugs 18(5)： p.555-562
顯示於類別:	[生物科技系(所)] 期刊論文

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