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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22205

    標題: Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by pterocarnin A from the bark of Pterocarya stenoptera via the Fas-mediated pathway.
    作者: Kuo, Po-Lin
    Hsu, Ya-Ling
    Sung, Shu-Chiao
    Ni, Wen-Chiu
    Lin, Ta-Chen
    Lin, Chun-Ching
    貢獻者: 生物科技系
    日期: 2007-06
    上傳時間: 2010-01-12 09:13:12 (UTC+8)
    出版者: Lippincott Williams & Wilkins
    摘要: Pterocarnin A, isolated from the bark of Pterocarya stenoptera (Juylandaceae), was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identify the anticancer mechanism of pterocarnin A, we assayed its effects on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that pterocarnin A induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that the Fas/Fas ligand apoptotic system is the main pathway of pterocarnin A-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of pterocarnin A in MCF-7 cells.
    關聯: Anti-Cancer Drugs 18(5): p.555-562
    Appears in Collections:[生物科技系(所)] 期刊論文

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