Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: enhancement of cytokine synthesis, CD11b expression, and phagocytosis

doi:10.1007/s00253-007-0880-5

CNU IR > Pharmacy and Science > Dept. of Biotechnology (including master's program) > Periodical Articles > Item 310902800/22197

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/22197

Title:	Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: enhancement of cytokine synthesis, CD11b expression, and phagocytosis
Authors:	Mei-Chun Kuo Chien-Yu Chang Tso-Lin Cheng Ming-Jiuan Wu
Contributors:	生物科技系
Keywords:	Cordyceps sinensis Immunomodulatory effect Phagocytosis Cytokine CD11b
Date:	2007-06
Issue Date:	2010-01-12 09:12:59 (UTC+8)
Publisher:	Springer
Abstract:	Cordyceps sinensis is widely used as a traditional medicine for treatment of a wide variety of diseases or to maintain health. The immunomodulatory activity of polysaccharides prepared from submerged cultured C. sinensis BCRC36421 was investigated in human peripheral blood. Results demonstrated that Fr. A (exo-polysaccharides, 0.025 ∼ 0.1 mg/ml) induced the production of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-10 dose-dependently. Fr. A, as low as 0.025 mg/ml, could significantly augment surface expression of CD11b in monocytes and polymorphonuclear neutrophils. Functional assay revealed that Fr. A (0.05 mg/ml) also elevated phagocytosis in monocytes and PMN. On the other hand, Fr. B (intracellular polysaccharides) only moderately induced TNF-α release, CD11b expression, and phagocytosis at the same concentrations. Our results indicate that the immunomodulatory components of submerged cultured C. sinensis mainly reside in the culture filtrate.
Relation:	Applied Microbiology and Biotechnology 75(4)： p.769-775
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles

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