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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22188

    標題: A high oxidised frying oil content diet is less adipogenic, but induces glucose intolerance in rodents.
    作者: Pei-Min Chao
    Hui-Ling Huang
    Chun-Huei Liao
    Shiau-Ting Huang
    Ching-jang Huang
    貢獻者: 保健營養系
    關鍵字: Oxidised frying oil
    Glucose intolerance: Rodents
    日期: 2007-01
    上傳時間: 2010-01-11 14:08:12 (UTC+8)
    摘要: Oxidised frying oil (OFO) and fish oil have been shown to be peroxisome proliferator-activated receptor (PPAR)α activators and their ingestion results in pleotropic peroxisome proliferator responses in rats. To examine the effect of dietary OFO on adiposity, four groups of weanling Sprague–Dawley rats were fed isoenergetically with, respectively, a low fat basal diet containing 5 g/100 g of fresh soybean oil (LSB) or a high fat diet containing 20 g/100 g of fresh soybean oil (HSB), OFO (HO) or fish oil (HF). The tissue mass, cell size and lipid/DNA ratio in the retroperitoneal fat pad and serum leptin levels were lowest in the HO group (P < 0·05), indicating that dietary OFO has a greater anti-adipogenic action than dietary fish oil. However, a tendency to hyperglycaemia was observed in the HO group (P = 0·0528). To examine the effect of dietary OFO on glucose tolerance, three groups of rats and three groups of mice were fed, respectively, the LSB, HSB or HO diet, and an oral glucose tolerance test was performed. After oral glucose load, the area under the curve for blood glucose (AUCglu) over 2 h was significantly higher, and that for serum insulin (AUCins) over 90 min was significantly lower, in the HO group than in the other two groups (P < 0·05). These results demonstrate that, in rats and mice, a high OFO diet is less adipogenic, but induces glucose intolerance.
    關聯: British Journal of Nutrition,v.98 n.1, pp.63-71
    Appears in Collections:[保健營養系(所) ] 期刊論文

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