The Preparation of Enoxacin-loaded Liposomes and its in Vitro Evaluation in Pig's Eye

Chia Nan University of Pharmacy & Science Institutional Repository > 嘉南學報 > 27 期 (2001) > Item 310902800/22060

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標題:	The Preparation of Enoxacin-loaded Liposomes and its in Vitro Evaluation in Pig's Eye 負載Enoxacin 微脂粒之製備及其在體外豬眼睛之評估
作者:	Hung-Hong Lin Hui-Mei Yu Yi-Hung Tsai Li-Ren Hsu
貢獻者:	藥學系
關鍵字:	Liposomes Enoxacin Transcorneal Pig's eye 微脂粒經眼角膜豬眼睛
日期:	2001
上傳時間:	2010-03-24 16:45:17 (UTC+8)
摘要:	Varing phospholipids were used to prepare liposomes which were used to perform the evaluation in trascorneal characteristics. Enoxacin was selected as a model drug incorporated in various liposomal formulations as a therapeutic dosage form. Using a combination of the ethanol injection technique and freeze-drying process,the encapsulation efficiency became 9-fold greater than that odtained by using a conventional film method. In the in vitro corneal perfusion studies,enoxacin loaded-liposome was transfered through cornea at aslower rate than free drug. However, enoxacin loaded-liposomes were accumulated primarily in the cornea. The increase in the drug corneal retention for the lipids conformed to the following order:DSPC>DPPC.DMPC. Finally. the DSC analysis was utilized to determine the interaction occuring between liposomes and cornea. The liposomes must be transferred into cornea to alter the constitute of cells and can be prodadly taken up by the cornea via endocytosis.
關聯:	嘉南學報 27 : p.89-96
顯示於類別:	[嘉南學報] 27 期 (2001) [藥學系(所)] 期刊論文

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