Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/21971
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    CNU IR > Chna Nan Annual Bulletin > No.28 (2002) >  Item 310902800/21971
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21971


    Title: 純化牡丹皮抽取物之毒性及對癌細胞之作用
    Determination of the cytotoxicity of purified extracts derived from paeonia suffruticosa and its effects on cancer cells
    Authors: 郭俊成
    陳榮秀
    林清宮
    丁秀玉
    Contributors: 化妝品應用與管理系
    Keywords: 牡丹皮
    純化物
    體外細胞毒性測試
    Paeonia suffruticosa
    Pure compound
    Cytotoxicity
    Date: 2003
    Issue Date: 2010-03-24 16:45:17 (UTC+8)
    Abstract: 牡丹皮又名丹皮,為芍藥科(Paeoniaceae)芍藥屬牡丹(Paeonia suffruticosa Andr.)之乾燥根皮。牡丹皮在中醫藥分類而言,屬於清熱量血類。其藥效有活血化瘀及清熱量血之用,活血即指防止血液凝集;就現代醫學而言,則指抑制血小板之凝集,抑制血中可溶性凝集因子之活化,血液凝固,及調節血液流變性;化瘀則指抑制血栓行程,促進血栓溶解,使血流順暢。近年牡丹皮更被證明可用於化妝品上。然而講求藥效外,其毒性的鑑定非常重要,必需了解其毒性方能安心使用。在本研究中我們選用fibroblost(纖維母細胞)(L929),以MTT及Neutral Red二種試劑檢測牡丹皮萃取物的細胞毒性。研究結果顯示牡丹皮之毒性甚低,可應用於化妝品。在抗癌實驗方面,以Tamoxifen為positive control(10-5M)有顯著之抑制作用,但同濃度之牡丹皮純化物PSC-K1,3,6對人類乳癌細胞MDA-MB231及T47D並沒有顯著的抑制效果。對其他癌細胞是否有抑制效果,則需要進一步探討。
    Relation: 嘉南學報 28期 : p.208-216
    Appears in Collections:[Chna Nan Annual Bulletin] No.28 (2002)
    [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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