Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway

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Title:	Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway
Authors:	Clay C. C. Wang Yi-Ming Chiang Po-Lin Kuo Jiunn-Kae Chang Ya-Ling Hsu
Contributors:	藥物科技研究所
Date:	2008-03
Issue Date:	2009-10-13 09:29:36 (UTC+8)
Publisher:	Wiley
Abstract:	Abstract: Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that norsolorinic acid induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of norsolorinic acid in MCF-7 cells.
Relation:	Basic and Clinical Pharmacology and Toxicology 102(6)：p.491-497
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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