Palladium-catalyzed 1,2-addition of organic halides and terminal alkynes to 7-oxabenzonorbornadiene; an efficient route to polyaromatic hydrocarbons

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Title:	Palladium-catalyzed 1,2-addition of organic halides and terminal alkynes to 7-oxabenzonorbornadiene;an efficient route to polyaromatic hydrocarbons
Authors:	Chun-Jung Kuo Shu-Jin Cheng Shu-Ting Chang Charng-Hsing Liu
Contributors:	醫藥化學系
Keywords:	Multicomponent reactions Palla�dium Oxabenzonorbornadiene Alkynes
Date:	2008-12
Issue Date:	2009-10-13 09:09:26 (UTC+8)
Abstract:	A three-component coupling reaction of organic halides with oxabicyclic alkenes and terminal alkynes was catalyzed by a palladium complex and a phase-transfer agent in the presence of aqueous NaOH. The reaction gave a series of 5,6-disubstituated 7-oxabenzonorbornene derivatives in good yields. The disubstituted products from oxabenzonorbornadiene can be readily converted into polyaromatic hydrocarbons by a Lewis acid mediated deoxyaromatization reaction.
Relation:	European Journal of Organic Chemistry 2008(3)：p.485 - 491
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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