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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21639

    標題: Potential of mean force for human lysozyme-camelid vhh hl6 antibody interaction studies
    作者: Yeng-Tseng Wang
    Jun-Min Liao
    Cheng-Lung Chen
    Zhi-Yuan Su
    Chang-Hung Chen
    Jeu-Jiun Hu
    貢獻者: 資訊管理系
    日期: 2008-04
    上傳時間: 2009-09-23 16:05:26 (UTC+8)
    摘要: Calculating antigen–antibody interaction energies is crucial for understanding antigen–antibody associations in immunology. To shed further light into this equation, we study a separation of human lysozyme–camelid vhh hl6 antibody (cAb-HuL6) complex. The c-terminal end-to-end stretching of the lysozyme–antibody complex structures have been studied using potential of mean force (PMF) calculations based on molecular dynamics (MD) and explicit water model. For the lysozyme–antibody complex, there are six important intermediates in the c-terminal extensions process. Inclusion of our simulations may help to understand the binding mechanics of lysozyme–cAb-HuL6 antibody complex.
    關聯: Chemical physics letters 455(4-6):p.284-288
    Appears in Collections:[資訊管理系] 期刊論文

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