English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18055/20253 (89%)
Visitors : 25123077      Online Users : 534
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21639


    標題: Potential of mean force for human lysozyme-camelid vhh hl6 antibody interaction studies
    作者: Yeng-Tseng Wang
    Jun-Min Liao
    Cheng-Lung Chen
    Zhi-Yuan Su
    Chang-Hung Chen
    Jeu-Jiun Hu
    貢獻者: 資訊管理系
    關鍵字: MOLECULAR-DYNAMICS
    SIMULATION
    日期: 2008-04
    上傳時間: 2009-09-23 16:05:26 (UTC+8)
    出版者: ELSEVIER SCIENCE BV
    摘要: Calculating antigen–antibody interaction energies is crucial for understanding antigen–antibody associations in immunology. To shed further light into this equation, we study a separation of human lysozyme–camelid vhh hl6 antibody (cAb-HuL6) complex. The c-terminal end-to-end stretching of the lysozyme–antibody complex structures have been studied using potential of mean force (PMF) calculations based on molecular dynamics (MD) and explicit water model. For the lysozyme–antibody complex, there are six important intermediates in the c-terminal extensions process. Inclusion of our simulations may help to understand the binding mechanics of lysozyme–cAb-HuL6 antibody complex.
    關聯: Chemical physics letters 455(4-6):p.284-288
    Appears in Collections:[資訊管理系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    97_74.pdf928KbAdobe PDF423View/Open
    index.html0KbHTML2114View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback