Shiunko and acetylshikonin promote reepithelialization, angiogenesis, and granulation tissue formation in wounded skin

doi:10.1142/S0192415X08005631

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/21584

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21584

Title:	Shiunko and acetylshikonin promote reepithelialization, angiogenesis, and granulation tissue formation in wounded skin
Authors:	Pao-Ju Lu Cheng Yang Ching-Nan Lin Chien-Feng Li Chin-Chen Chu Jhi-Joung Wang Jen-Yin Chen 褚錦承
Contributors:	休閒保健管理系
Keywords:	Acetylshikonin Shiunko Skin Wound Healing
Date:	2008-02
Issue Date:	2009-07-21 14:36:33 (UTC+8)
Abstract:	Shiunko is a traditional botanic formula (ointment) used clinically for treating wounded skin. The aim of the present study was to compare the effects of Shiunko and acetylshikonin, and its active ingredient, with those of gentamicin and silver sulfadiazine ointments, two disinfectants for wound healing. Wounds were cut in the backs of Sprague-Dawley rats. Different bacterial inoculations (Pseudomonas aeruginosa and Staphylococcus aureus) and treatments (Shiunko, acetylshikonin, gentamicin, silver sulfadiazine, and vehicle ointments) were used to treat these wounds. We found that rats treated with Shiunko and acetylshikonin on both the sterilized and infected wounds showed higher rates of reepithelialization than those treated with the other ointments (p < 0.05) during a 7-day observation. In the histological study, rats treated with Shiunko and acetylshikonin on both the sterilized and infected wounds showed greater reepithelialization, angiogenesis, and granulation tissue formation than rats treated with the other ointments (p < 0.05) on day 5 after the wounds had been sutured. Differences between rats treated with Shiunko and acetylshikonin ointments were not statistically significant. In conclusion, topically applying Shiunko and acetylshikonin on wounded skin promoted wound healing. Both ointments were effective on sterilized and infected wounds.
Relation:	The American journal of chiness medicine 36(1)：p.115-123
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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