Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice

doi:10.1211/jpp.60.2.0013

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/21577

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题名:	Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice
作者:	Lisu Wang Choi-Lan Ha Tso-Lin Cheng Su-Yun Cheng Tzi-Wei Lian Ming-Jiuan Wu
贡献者:	食品科技系保健營養系生物科技系
日期:	2008-02
上传时间:	2009-07-21 14:07:10 (UTC+8)
出版者:	Pharmaceutical Press-Royal Pharmaceutical Soc Great Britian
摘要:	Grifola frondosa fruiting body (Maitake) has been used as a dietary supplement due to its antitumour and immunomodulatory properties. The aim of this study was to evaluate the immunomodulatory effects of orally administered submerged cultivated G. frondosa mixture, including both mycelium and culture broth, in a healthy murine model. Composition analyses showed that submerged cultivated G. frondosa mixture contained only 32.48% carbohydrate, which was less than half of fruiting bodies. The content of adenosine, a potential immunomodulatory agent in medicinal mushrooms, was 2.8 mg g−1. After feeding 8-week-old female BALB/cByJ mice with AIN-93G diet containing 0% (C), 1% (G1), 3% (G3) or 5% (G5) (wt/wt) G. frondosa mixture for 31 days, neither body weight nor the outward appearance of organs showed any significant difference among different diet groups. Splenocyte subpopulation, mitogen-activated cytokine release and splenic NK activity were not affected by G. frondosa administration, either. On the other hand, the phagocytic activity was enhanced in leucocytes of groups G3 and G5, without exerting detectable levels of serum proinflammatory cytokines. These results suggested that oral administration of submerged cultivated G. frondosa mixture may enhance host innate immunity against foreign pathogens without eliciting adverse inflammatory response
關聯:	Journal of pharmacy and pharmacology 60(2)：p.237-243
显示于类别:	[Dept. of Food Science & Technology] Periodical Articles [Dept. of Health and Nutrition (including master's program)] Periodical Articles [Dept. of Biotechnology (including master's program)] Periodical Articles

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