Urinary excretion of toluene diisocyanates in rats following dermal exposure

doi:10.1002/jat.1266

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/21556

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题名:	Urinary excretion of toluene diisocyanates in rats following dermal exposure
作者:	Hui-Jung Yeh Wei-Chao Lin Tung-Sheng Shih Perng-Jy Tsai Shan-Tair Wang Ho-Yuan Chang 葉慧容林維炤
贡献者:	老人服務事業管理系化粧品科技研究所
关键词:	toluene diisocyanate skin absorption kinetics toluene diamine dermal exposure
日期:	2008-03
上传时间:	2009-07-20 09:53:27 (UTC+8)
摘要:	Toluene diisocyanates (TDI) are commonly used in polyurethane (PU)-related products. TDIs have been documented as the leading cause of occupational asthma. Skin exposure to TDI in the workplace is common. However, no studies in the literature have investigated the exact biomarker concentration profile for skin TDI absorption through any in vivo animal studies. In this study a rat model was used to evaluate the TDI skin absorption to explore the doseresponse pattern and to determine the kinetic characteristics of urinary toluene diamine (U-TDA) during skin exposure. TDIs were topically exposed on the dorsum of rat skin at 0.2%, 1% and 5%. Consecutive urine samples were collected for 6 days and U-TDA were analysed using GC/ECD. It was demonstrated in this rat study that absorption of 2,4- and 2,6-TDI through skin contact is possible. A clear dose-dependent skin absorption relationship for 2,4- and 2,6-TDI was demonstrated by the AUC, C max findings and accumulative amounts (r ≥ 0.968). U-TDA concentration profiles in 6-day consecutive urine samples fit well in the first-order kinetics, although higher order kinetics could not be excluded for the high dose. The apparent half-lives for excretory urinary TDA were about 20 h consistent at various skin exposures. It is concluded that skin absorption of TDI was confirmed in a rat model and a clear dose-dependent skin absorption relationship for 2,4- and 2,6-TDI was demonstrated. Excretory U-TDA concentrations in 6-day consecutive urine samples via skin exposure reveal the first-order kinetics and the half-lives were about 20 h. Copyright © 2007 John Wiley & Sons, Ltd.
關聯:	Journal of applied toxicology28(1)：p.189-195
显示于类别:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles [Dept. of Senior Service and Health Management] Periodical Articles

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