含蔗糖及Ac-Di-Sol/Primojel之Acetaminophen錠劑在酸性及中性媒液間之崩散與溶離有很大之差異。本計畫之目的即是在探討此一現象之機轉及尋求解決差異之方法。研究發展溶離差異原因與主成分之親水程度與溶離媒液之酸鹼值有關。這種差異在Acetaminophen、Primojel和蔗糖合用時更明顯,我們認為這與Primojel在酸性媒液之效率受抑制、蔗糖之強黏合性、主成分之厭水性,二個媒液間之酸鹼度差異有關。增加Primojel之用量或加入界面活性劑能大大地減低溶離差異。 The disintegration and dissolution of acetaminophen tablets containing sucrose and Ac-Di-Sol/Primojel was significantly different between acidic and neutral media. The purpose of this study was to investigate the mechanism of this phenomenon and to propose a way of reducing the dissolution difference between the two media. The dissolution differences were found to be largely related to the hydrophobicity of the active ingredient and pH difference of the two media. This difference was even more evident under the condition where acetaminophen, sucrose, and Primojel were combined. The dissolution difference was therefore attributed to the depressed function of Primojel in the acidic medium, the stronger binding of sucrose, the hydrophobicity of the active ingredient and pH difference of the two media. Increasing the concentration of Primojel or incorporating the surfactant in the tablet can thus greatly decrease the dissolution difference between acidic and neutral media.
