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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/1814

    標題: ENOXACIN 微脂粒包覆處方之經皮離子電透入輸藥法研究
    Studies on Transdermal Iontophoretic Delivery of Liposome-Encapsulated Enoxacin
    作者: 方嘉佑
    Jia-You Fang
    貢獻者: 藥學系
    關鍵字: 微脂粒
    Percutaneous absorption
    Transdermal iontophoretic delivery
    日期: 1998
    上傳時間: 2008-07-18 16:08:00 (UTC+8)
    出版者: 台南縣:嘉南藥理科技大學藥學系
    摘要: The major purpose of this work was to study the effect of various liposome formulations on transdermal iontophoretic transport of enoxacin through excised rat skin. The electrochemical stability of these liposomes was also evaluated. The enoxacin encapsulation percentage was significantly enhanced after 6h incubation in electric field, whereas the fusion of enoxacin liposomes was inhibited by application of electric current. The results of iontophoretic transport showed that the permeability of enoxacin released from liposomes was higher compared with that of free drug form. The iontophoretic permeability of enoxacin released from liposomes increased with a decrease in fatty acid chain lengths of phospholipid, which can be due to the various phase transition temperature of phospholipids. Incorporation of charged phospholipid in liposomes resulted in an alteration of transdermal behavior of enoxacin: the iontophoretic permeation as well as enoxacin amount partitioned in skin were greatly reduced after incorporation of stearyl amine in liposomes, which can be attributed to the competitive ion effect. The stratum corneum-based liposomes showed the highest amount of enoxacin partitioned into skin depot. The results of employing cathodal iontophoresis on negative charged liposomes suggested that liposomal vesicles or phospholipids may carry enoxacin into deeper skin strata via follicular route.
    Appears in Collections:[藥學系(所)] 科技部計畫

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