鋯錯合物促進比咯化合物之合成

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Title:	鋯錯合物促進比咯化合物之合成 Zirconocene Complexes Promote The Synthsis of Pyrroles
Authors:	李進送
Contributors:	醫藥化學系
Keywords:	單氮二烯 1-鋯-2-氮-環戊-3-烯比咯 1-azadiene pyrrole 1-zircona-2- azacyclopent-3-ene
Date:	2002
Issue Date:	2008-06-30 14:41:57 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學醫藥化學系
Abstract:	1-鋯-2-氮-環戊-3-烯錯合物在室溫下可與乙酸乙酯或DMF進行插入反應，經由氫氧化鈉水溶液水解後，可得到不錯產率的比咯。另外，我們也可直接使用有機鋰或鎂粉還原Cp2ZrCl2，再加入單氮二烯、乙酸乙酯或DMF，水解後亦可直接產生比咯化合物。我們亦已推出此反應之詳細反應機構。 Insertion of ethylacetate or DMF into 1-zircona-2-azacyclopent-3-ene complexes at 50 oC affords pyrroles in moderate yield when they quenched with KOH aqueous. In addition, we also can directly add n-BuLi or Mg powder into Cp2ZrCl2 THF solution, followed by addition of 1-azadiene, ethylacetate or DMF to produce pyrroles after hydrolysis. Here, we have proposed a detail mechanism for this reaction.
Relation:	計畫編號：CNAC9110
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Chna Project

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