Soft capsules as a pharmaceutical dosage form have the advantages of being: high bioavailability for nonpolar drug in oil solution, stable toward oxidation and hydrolysis, and content uniformity. However, it has also some limitations such as: the raw material is animal origin, it breaks up in the stomach fast. The purpose of this study is to optimize the technology to make the soft capsule by a semi-automatic soft capsule machine. Then, add the function of controlled release to this traditional dosage form of soft capsule. Finally, do a preliminary screening study on the replacement or modification of the raw material. 軟膠囊具有，對水難溶解性藥品高生體可用率之優點，同時內容均勻且安定，空氣及溼氣對膠囊之通透性皆低。
但是它也有動物來源之缺點，對素食者不適用。而且狂牛病之傳染，使得人們更有疑慮。
本計劃繼續研究半自動軟膠囊機製造軟膠囊之技術，也尋找開發軟膠囊之新原料。
