Investigation of hydrogel nanoparticles delivery systems for anti-obesity drug

CNU IR > Pharmacy and Science > Dept. of Pharmacy > CNU Project > Item 310902800/1082

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Title:	Investigation of hydrogel nanoparticles delivery systems for anti-obesity drug 減肥藥物之凝膠型耐米微粒藥物輸移系統
Authors:	林恆弘
Contributors:	藥學系
Keywords:	水不溶奈米微粒親水膠體 phenylpropanolamine Water-insoluble Nanoparticles Hydrogel
Date:	2003
Issue Date:	2008-06-26 10:40:00 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學藥學系
Abstract:	Suspensions composed of numberless nanoparticles were used for improved solubilization of phenylpropanolamine (PPA). Nanoparticles encapsulating PPA HCl were prepared using the solid jelly pulverization technique. The size of the PPA HCl - hydrogel nanoparticles was assessed using a LS particle size analyzer and scanning electron microscopy（SEM）. The rheological properties of suspensions are characterized by Cone and Plate Viscometer. In addition, any drug-polymer interactions were assessed using a differential scanning calorimeter (DSC). The results show that solid jelly pulverization technique yielded PPA HCl hydrogel nanoparticles with a mean diameter of 40 nm to 800 nm. Based on our release profiles, following an initial burst release of 40% to 50% PPA HCl, the release was sustained over the 24-hours study period. Moreover, while pH value of PPA HCl – loaded nanoparticles suspension increased over 3, no significant agglomeration of insoluble drug were grown. The DSC measurements indicated that the chemical interaction does not occur among the components during manufacturing processes and reconstituting lyophilized powder. The above results will be helpful to possible development of the other water-insoluble drug delivery systems. 本研究採用含無數奈米微粒之懸液來改善難溶性藥物phenylpropanolamine (PPA)之溶解度。奈米微粒包覆PPA HCl是以固態凝膠研磨技術來完成，負載PPA HCl之親水膠體奈米微粒以雷射粒徑分析儀與掃瞄式電子顯微鏡來檢測其粒子大小，懸液之流體特性是以Cone and Plate黏度計來評估，此外，藥物與膠體聚合物間之交互作用則是以熱卡式分析儀來檢視。結果顯示，以固態凝膠研磨技術所獲得的PPA HCl親水膠體奈米微粒其平均粒徑是介於40到800奈米之間，基於體外藥物釋離圖形，PPA HCl於最初突釋40%至50%後，其釋離可維持24小時的持續釋放，而且，當負載藥物奈米微粒之懸液其酸鹼值上揚超過3時，也未有不溶性藥物明確的凝結物生成；經由熱分析的觀察得知，不論是製造或是凍晶乾燥粉體加水還原之過程，各組成分間均未有明顯的化學交互作用發生。綜合上述之實驗結果，將有助於協助發展其他難溶性藥物之輸移系統。
Relation:	計畫編號：CNPH9206
Appears in Collections:	[Dept. of Pharmacy] CNU Project

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