中藥槐米與地骨皮在化妝品之生物活性研究

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Title:	中藥槐米與地骨皮在化妝品之生物活性研究 Studies on the cosmetic bioactivity for Sophora japonica L. and Lycium chinense Mill.
Authors:	馮皓雲 Hao-yun Feng
Contributors:	丁秀玉嘉南藥理科技大學：化妝品科技研究所
Keywords:	槐米美白抗氧化地骨皮 antioxidative Lycium chinense Mill
Date:	2007
Issue Date:	2008-12-03 11:16:27 (UTC+8)
Abstract:	隨著經濟發展，時代進步，化妝品的需求量日益殷切。而在崇尚自然產品的趨勢下，目前的化粧品多是傾向運用天然植物做為原料或添加劑。故本研究選定以槐米及地骨皮二種中藥進行抗氧化及美白之分離純化。本研究從槐米的95%乙醇萃取物中分離純化而得四種純物質：Luteolin 7-O-β-D-glucoside (1)、Kaempferol (2)、Rutin (3)、 Quercetin(4)。而由地骨皮的95%乙醇萃取物中分離純化而得一種純物質：Scopoletin (5)。由上述二種中藥分離的五個化合物，均具有掃除自由基DPPH 和抑制酪氨酸酶的活性。進一步對具有抑制酪氨酸酶活性的有效成分Kaempferol (2)進行酵素動力學的研究，發現其在抑制酪氨酸酶活性機制上是屬於競爭性的抑 Following the development of economics, the cosmetics market has been boosted as well. The application of herb natural products as components of the cosmetic products is a trend at present in the cosmetic industry. Two herbs, Sophora japonica L. and Lycium chinense Mill., were studied in order to isolate their antioxidative and whitening components. From the 95% ethanol extract of Sophora japonica L., four components were isolated: luteolin 7-O-β-D-glucoside (1), kaempferol (2), rutin (3) and quercetin (4). From the 95% ethanol extract of Lycium chinense Mill., one compound was isolated: scopoletin (5). Among of isolated five compounds, Luteolin 7-O-β-D-glucoside (1), kaempferol (2), rutin (3), quercetin (4), and scopoletin (5) show DPPH scavenging activity and inhibit tyrosinase activity. In the kinetic analysis, component kaempferol (2) was shown to inhibit mushroom tyrosinase in competitive manner.
Relation:	校內校外均不公開
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Dissertations and Theses

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