茄紅素之固體製劑研發：錠劑劑型

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Title:	茄紅素之固體製劑研發：錠劑劑型 Investigation of solid products for lycopene：tablet dosage forms
Authors:	林恆弘
Contributors:	藥學系
Keywords:	茄紅素吸濕性固體製劑粉體錠劑崩散 Lycopene Hygroscopicity solid product powder tablet disintegration
Date:	2004
Issue Date:	2008-06-06 16:24:42 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學藥學系
Abstract:	現今的消費者使用乾燥製品的情形相當普遍，就經濟上與方便性而言，其具有可增加製品的架貯期、減少包裝、降低價格與改善操作特性等優點。本研究中，乾燥之蕃茄粉末混合適當的賦形劑經壓製成為咀嚼錠或快速溶解之錠劑。接著評估其崩散劑性質—錠劑崩散時間與受壓破裂壓力；結果顯示，崩散劑的種類、添加模式、添加濃度與相對密度顯著影響錠劑的崩散時間，但對錠劑受壓破裂壓力的影響則不顯著。 Dry products have a high level of popularity with today’s consumers. Dry mixes are economical and convenient with increased shelf-life, reduced packaging, decreased cost and improved handling properties. In the study, the dried tomato powder combined with the appropriated excipients was pressed into chewable or a quick dissolve tablet dosage form. The disintegrant properties – tablet disintegration time and crushing strength were evaluated. The results show that the kinds of disintegrants, the mode of addition of disintegrants, disintegrant concentration and relative density had a significant impact on the disintegration time, but not on the crushing strength.
Relation:	計畫編號:CNPH9306
Appears in Collections:	[Dept. of Pharmacy] CNU Project

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