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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/880


    標題: Preparation and release studies of controlled-release pellets containing enteric polymer-stability studies
    作者: 宋國峻
    貢獻者: 藥學系
    日期: 2004
    上傳時間: 2008-06-06 16:24:41 (UTC+8)
    出版者: 台南縣:嘉南藥理科技大學藥學系
    摘要: 隨控釋劑型藥物的推動進展,其中控釋圓粒以其釋藥速率受生理因素影響
    小、副作用較少以及同時可進行多種成分的配合等特有的優點使其日益受到人們
    的重視,成為口服緩控釋製劑的發展方向。所以本研究採用ketoprofen 當模式
    藥物,以膜衣包覆方式來製備控制釋放圓粒,分別以乙基纖維素(EC)、羥丙基
    纖維素(HPCL)當粘合劑,將ketoprofen 噴於惰性糖蕊圓粒上;再於藥蕊圓粒上
    包覆控釋膜衣。以不溶性膜衣材質乙基纖維素與腸溶性膜衣材質虫膠(Shellac)
    當致孔劑做為控釋圓粒外表包覆的材料,並以體外溶離試驗來探討包覆後貯存環
    境對藥物釋放影響之效應。
    Appears in Collections:[藥學系(所)] 校內計畫

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