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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/6162

    標題: 臺灣健康志願者nimesulide藥物動力學之研究
    The pharmacokinetics of nimesulide in Taiwanese subjects
    作者: 翁埈德
    Cheung-Ter Ong
    貢獻者: 宋國峻
    關鍵字: 藥物基因學
    COX-2 抑制劑
    日期: 2005
    上傳時間: 2008-10-31 16:15:40 (UTC+8)
    摘要: 背景及目的
    在健康之台灣志願者口服100mg的nimesulide後,平均AUC0-∞為59.27±22.78μg‧h/ml,為西方人的1.14到3.73倍。Cmax為6.09±1.10μg/ml為西方人的0.94到2.13倍。清除率為西方人的31.0%到71.7%之間。綜合此結果及文獻資料,顯示台灣人較西方人有較高之Cmax、AUC0-∞,較低的清除率及較低的volume distribution。而Tmax及t1/2則和西方人差異不大。
    Background and purpose
    Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor exerting analgesic, antipyretic and antiplatelet activity. COX-2 inhibitor was shown to have less gastrointestinal adverse effects. However, its cardiovascular side effect has been drawn much attention recently. The purpose of the study is to compare the pharmacokinetics of nimesulide(via oral administration) in Taiwanese subjects to that of Western peoples.
    Twelve healthy Taiwanese subjects (25 to 39 years) enrolled in the study. Each subject received a single oral dose of 100mg numesulide in fasting state. After orally administrated, blood samples were drawn up to 24 hours. The plasma concentrations of nimesulide were determined using HPLC and pharmacokinetic parameters were derived from nimesulide plasma concentration-time profiles..
    Following oral administration of 100mg nimesulide in Taiwanese subjects, the AUC0-∞was 59.27±22.78μg‧h/ml, which is 1.14 to 3.73 times to the results in Western peoples. The Cmax was 6.09±1.10μg/ml, which is 0.94 to 2.13 times higher compared to the results of Western peoples. Clearance in Taiwanese was only 31.0 to 71.7% compared to the clearance of Western groups. Both data as well as previous publication, showed taht higher Cmax , AUC and lower clearance, lower volume distribution in Taiwanese subjects were observed compared to those in Western people. Tmax and t1/2 did not differ significantly between Taiwanese and Western people.
    The pharmacokinetics parameters of nimesulide in Taiwanese subjects may be different from other ethnic populations. More pharmacokinetic and pharmcodynamic studies are needed to determine the optimal dosage of nimesulide for Taiwanese.
    關聯: 校內外均一年後公開
    Appears in Collections:[生物科技系(所)] 博碩士論文

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